Guest Stars by Episode
Notable Guest Stars:
| Episode | Guest Star | Character | # |
|---|---|---|---|
| Season | 1 | ||
| 1.01 – Pilot | Rachel Dratch | Greta Johanssen | 1 |
| 1.02 – The Aftermath | Rachel Dratch | Maria | 1 |
| 1.03 – Blind Date | Stephanie March | Gretchen Thomas | 1 |
| 1.05 – Jack-tor | Ghostface Killah | Himself | 1 |
| 1.06 – Jack Meets Dennis | Dean Winters | Dennis Duffy | 1 |
| Rachel Dratch | Elizabeth Taylor | 1 | |
| 1.07 – Tracy Does Conan | Dean Winters | Dennis Duffy | 2 |
| Conan O’Brien | Himself | 1 | |
| Chris Parnell | Dr. Leo Spaceman | 1 | |
| Rachel Dratch | Blue Dude | 1 | |
| 1.08 – The Break Up | Dean Winters | Dennis Duffy | 3 |
| Rachel Dratch | Pamela Smew | 1 | |
| Chris Hansen | Himself | 1 | |
| 1.09 – The Baby Show | Chris Parnell | Dr. Leo Spaceman | 2 |
| Rachel Dratch | Greta Johanssen | 2 | |
| 1.10 – The Rural Juror | Chris Parnell | Dr. Leo Spaceman | 3 |
| Whoopi Goldberg | Herself | 1 | |
| Rachel Dratch | Barbra Walters | 1 | |
| 1.11 – The Head and the | Peter Hermann | Gary (The Hair) | 1 |
| Hair | Brian McCann | The Head | 1 |
| John McEnroe | Himself | 1 | |
| 1.12 – Black Tie | Isabella Rossellini | Bianca | 1 |
| Paul Reubens | Gerhardt Habsburg | 1 | |
| Will Forte | Tomas | 1 | |
| 1.13 – Up All Night | Isabella Rossellini | Bianca | 2 |
| Rachel Dratch | Vlem | 1 | |
| Jason Sudeikis | Floyd | 1 | |
| Sherri Shepherd | Angie Jordan | 1 | |
| Joy Behar | Herself | 1 | |
| 1.14 – The C Word | Rachel Dratch | Greta Johanssen | 3 |
| Rip Torn | Don Geiss | 1 | |
| 1.15 – Hardball | Rachel Dratch | Martha Blanch | 1 |
| Chris Matthews | Himself | 1 | |
| Tucker Carlson | Himself | 1 | |
| David Alan Basche | Alan | 1 | |
| 1.16 – The Source Awards | Jason Sudeikis | Floyd | 2 |
| Wayne Brady | Steven Black | 1 | |
| LL Cool J | Ridikolus | 1 | |
| Ghostface Killah | Himself | 2 | |
| 1.17 – The Fighting Irish | Nathan Lane | Eddie Donaghy | 1 |
| Jason Sudeikis | Floyd | 3 | |
| Molly Shannon | Katherine Catherine | 1 | |
| Brian Murray | Jack’s Dad | 1 | |
| Anna Chlumsky | Liz Lemler | 1 | |
| Siobhan Fallon | Patricia | 1 | |
| 1.18 – Fireworks | Will Arnett | Devon Banks | 1 |
| Chris Parnell | Dr. Spaceman | 4 | |
| Jason Sudeikis | Floyd | 4 | |
| Al Roker | Himself | 1 | |
| Maury Povich | Himself | 1 | |
| 1.19 – Corporate Crush | Jason Sudeikis | Floyd | 5 |
| Rip Torn | Don Geiss | 2 | |
| Emily Mortimer | Phoebe | 1 | |
| 1.20 – Cleveland | Jason Sudeikis | Floyd | 6 |
| Emily Mortimer | Phoebe | 2 | |
| Lester Holt | Himself | 1 | |
| 1.21 – Hiatus | Jason Sudeikis | Floyd | 7 |
| Emily Mortimer | Phoebe | 3 | |
| Chris Parnell | Dr. Leo Spaceman | 5 | |
| Elaine Stritch | Colleen Donaghy | 1 | |
| Rachel Dratch | Dr. Beauvior | 1 | |
| Sean Hayes | Jesse Pacell | 1 | |
| Lester Holt | Himself | 2 | |
| Season | 2 | ||
| 2.01 – Seinfeld Vision | Jerry Seinfeld | Himself | 1 |
| 2.02 – Jack Gets in the | Chris Parnell | Dr. Spaceman | 6 |
| Game | Will Arnett | Devon Banks | 2 |
| Rip Torn | Don Geiss | 3 | |
| Sherri Shepherd | Angie Jordan | 2 | |
| Marceline Hugot | Kathy Geiss | 1 | |
| 2.03 – The Collection | Sherri Shepherd | Angie Jordan | 3 |
| Steve Buscemi | Lenny Wosniak | 1 | |
| Jackie Mason | Himself | 1 | |
| 2.04 – Rosemary’s Baby | Carrie Fisher | Rosemary Howard | 1 |
| Paul Scheer | Donny Lawson | 1 | |
| 2.05 – Greenzo | David Schwimmer | Greenzo | 1 |
| Al Gore | Himself | 1 | |
| Meredith Vieira | Herself | 1 | |
| Paula Pell | Paula Hornberger | 1 | |
| 2.06 – Somebody to | Edie Falco | C.C. | 1 |
| Love | Fred Armisen | Raheem | 1 |
| Kristen Wiig | Candace Van der Shark | 1 | |
| 2.07 – Cougars | Val Emmich | Jamie | 1 |
| 2.08 – Secrets and Lies | Edie Falco | C.C. | 2 |
| James Carville | Himself | 1 | |
| 2.09 – LudaChristmas | Elaine Stritch | Colleen Donaghy | 2 |
| Andy Richter | Mitch Lemon | 1 | |
| Anita Gillette | Margret Lemon | 1 | |
| Buck Henry | Dick Lemon | 1 | |
| 2.10 | Edie Falco | C.C. | 3 |
| Edward Herrmann | Walter | 1 | |
| Gladys Knight | Herself | 1 | |
| 2.11 – MILF Island | Rob Huebel | Himself | 1 |
| 2.12 Subway Hero | Dean Winters | Dennis Duffy | 4 |
| Tim Conway | Bucky Bright | 1 | |
| Mayor Bloomberg | Himself | 1 | |
| 2.13 – Succession | Chris Parnell | Dr. Leo Spaceman | 7 |
| Will Arnett | Devon Banks | 3 | |
| Rip Torn | Don Geiss | 4 | |
| Marceline Hugot | Kathy Geiss | 2 | |
| 2.14 – Sandwich Day | Jason Sudeikis | Floyd | 8 |
| Rip Torn | Don Geiss | 5 | |
| Marceline Hugot | Kathy Geiss | 3 | |
| Brian Dennehy | Mickey J | 1 | |
| 2.15 – Cooter | Matthew Broderick | Cooter Burger | 1 |
| Dean Winters | Dennis Duffy | 5 | |
| Edie Falco | C. C. | 4 | |
| Marceline Hugot | Kathy Geiss | 4 | |
| Paul Scheer | Donny Lawson | 2 | |
| Season | 3 | ||
| 3.01 – Do-Over | Will Arnett | Devon Banks | 4 |
| Megan Mullally | Bev | 1 | |
| 3.02 – Believe in the Stars | Oprah | Herself | 1 |
| 3.03 – The One With the | Jennifer Aniston | Claire Harper | 1 |
| Cast of Night Court | Night Court Cast | Themselves | 1 |
| 3.04 – Gavin Volure | Steve Martin | Gavin Volure | 1 |
| John McEnroe | Himself | 2 | |
| 3.05 – Reunion | Rip Torn | Don Geiss | 6 |
| Marceline Hugot | Kathy Geiss | 6 | |
| Diane Neal | Erin | 1 | |
| Robyn Lively | Kelsey | 1 | |
| Janel Moloney | Jessica | 1 | |
| 3.06 – Christmas Special | Elaine Stritch | Colleen Donaghy | 3 |
| 3.07 – Senor MachoSolo | Salma Hayek | Elisa | 1 |
| Sherri Shepherd | Angie Jordan | 4 | |
| Peter Dinklage | Stewart | 1 | |
| 3.08 – Flu Shot | Chris Parnell | Dr. Spaceman | 8 |
| Salma Hayek | Elisa | 2 | |
| 3.09 – Retreat to Move Forward | Chris Parnell | Dr. Spaceman | 9 |
| 3.10 – Generalissimo | Salma Hayek | Elisa | 3 |
| Jon Hamm | Dr. Drew Baird | 1 | |
| Matt Lauer | Himself | 1 | |
| 3.11 – St. Valentine’s Day | Salma Hayek | Elisa | 4 |
| Jon Hamm | Dr. Drew Baird | 2 | |
| Maria Thayer | Jennifer Rodgers | 1 | |
| 3.12 – Jalisa | Rip Torn | Don Geiss | 7 |
| Salma Hayek | Elisa | 5 | |
| Meredith Vieira | Herself | 2 | |
| Larry King | Himself | 1 | |
| 3.13 – Goodby, My Friend | Patti LuPone | Sylvia | 1 |
| John Lithgow | Himself | 1 | |
| 3.14 – The Funcooker | Chris Parnell | Dr. Spaceman | 10 |
| 3.15 – The Bubble | Jon Hamm | Dr. Drew Baird | 3 |
| Meredith Vieira | Herself | 3 | |
| Bobb’e J. Thompson | Tracy Jr. | 1 | |
| 3.16 – Apollo, Apollo | Dean Winters | Dennis Duffy | 6 |
| Adam West | Himself | 1 | |
| 3.17 – Cutbacks | Roger Bart | Brad Halster | 1 |
| Don Pardo | Sid | 1 | |
| 3.19 – The Ones | Salma Hayek | Elisa | 6 |
| Brain Williams | Himself | 1 | |
| 3.20 – The Natural Order | Elaine Stritch | Colleen Donaghy | 4 |
| Steve Buscemi | Lenny Wozniak | 2 | |
| 3.21 – Mama Mia | Steve Buscemi | Lenny Wozniak | 3 |
| Alan Alda | Milton | 1 | |
| 3.22 – Kidney Now | Chris Parnell | Dr. Spaceman | 11 |
| Sherri Shepherd | Angie Jordan | 5 | |
| Paula Pell | Paula | 2 | |
| Alan Alda | Milton | 2 | |
| Clay Aiken | Himself | 1 | |
| Mary J. Blige | Herself | 1 | |
| Elvis Costello | Himself | 1 | |
| Sheryl Crow | Herself | 1 | |
| Adam Lavine | Himself | 1 | |
| Season | 4 | ||
| 4.01 – Season Four | Steve Buscmei | Lenny Wozniak | 4 |
| Paula Pell | Paula Hornberger | 3 | |
| 4.02 – Into the Crevasse | Will Arnett | Devon Banks | 5 |
| 4.03 – Stone Mountain | Betty White | Herself | 1 |
| Jimmy Fallon | Himself | 1 | |
| Jeff Dunham | Rick Wayne | 1 | |
| 4.04 – Audition Day | Marceline Hugot | Kathy Geiss | 7 |
| Brian Williams | Himself | 1 | |
| Martin Scorsese | Himself | 1 | |
| Christopher Walken | Himself | 1 | |
| Gilbert Gottfried | Himself | 1 | |
| 4.04 – Audition Day | Marceline Hugot | Kathy Geiss | 7 |
| 4.05 – The Problem Solvers | Cheyenne Jackson | Danny | 1 |
| Padma Lakshmi | Herself | 1 | |
| 4.06 – Sun Tea | Chris Parnell | Dr. Spaceman | 12 |
| Marceline Hugot | Kathy Geiss | 8 | |
| Al Gore | Himself | 2 | |
| Bobb’e J. Thompson | Tracy Jr. | 2 | |
| Nathan Corddry | Brian | 1 | |
| 4.07 – Dealbreakers Talk Show | Chris Parnell | Dr. Spaceman | 13 |
| Will Arnett | Devon Banks | 6 | |
| Sherri Shepherd | Angie Jordon | 6 | |
| Whoopi Goldberg | Herself | 2 | |
| 4.08 – Secret Santa | Cheyenne Jackson | Danny | 2 |
| Julianne Moore | Nancy Donovan | 1 | |
| Larry Wilcox | Himself | 1 | |
| 4.09 – Klaus and Greta | James Franco | Himself | 1 |
| Matt Lauer | Himself | 2 | |
| 4.10 – Black Light Attack! | Cheyenne Jackson | Danny | 1 |
| Dr. Sanjay Gupta | Himself | 3 | |
| 4.11 – Winter Madness | Julianne Moore | Nancy Donovan | 2 |
| 4.12 – Verna | Jan Hooks | Verna | 1 |
| 4.13 – Anna Howard Shaw Day | Jason Sudeikis | Floyd | 9 |
| Dean Winters | Dennis Duffy | 7 | |
| Jon Hamm | Dr. Drew Baird | 4 | |
| Elizabeth Banks | Avery Jessup | 1 | |
| John Bon Jovi | Himself | 1 | |
| Horatio Sanz | Maynard | 1 | |
| 4.14 – Future Husband | Elizabeth Banks | Avery Jessup | 2 |
| Brian Williams | Himself | 3 | |
| Michael Sheen | Wesley | 1 | |
| Jack Welch | Himself | 1 | |
| 4.15 – Don Geiss, America and Hope | Michael Sheen | Wesley | 2 |
| Marceline Hugot | Kathy Geiss | 9 | |
| 4.16 – Floyd | Jason Sudeikis | Floyd | 10 |
| Cheyenne Jackson | Danny | 4 | |
| Meredith Viera | Herself | 4 | |
| Lester Holt | Himself | 3 | |
| Kathy Lee Gifford | Herself | 1 | |
| Hoda Kotb | Herself | 1 | |
| 4.17 – Lee Marvin vs Derek Jeter | Elizabeth Banks | Avery Jessup | 3 |
| Julianne Moore | Nancy Donovan | 3 | |
| Will Ferrell | Shane Hunter | 1 | |
| 4.19 – Argus | Marceline Hugot | Kathy Geiss | 10 |
| Will Forte | Paul | 1 | |
| 4.20 – The Moms | Elaine Stritch | Colleen Donaghy | 5 |
| Cheyenne Jackson | Danny | 5 | |
| Elizabeth Banks | Avery Jessup | 4 | |
| Jan Hooks | Verna | 2 | |
| Anita Gillette | Margret Lemon | 2 | |
| Patti LuPone | Sylvia | 2 | |
| Will Ferrell | Bitch Hunter | 2 | |
| Novella Nelson | Tracy’s Mom | 1 | |
| Buzz Aldrin | Himself | 1 | |
| 4.21 – Emanuelle Goes to | Jason Sudeikis | Floyd | 11 |
| Dinosaur Land | Dean Winters | Dennis | 8 |
| Jon Hamm | Dr. Drew Baird | 5 | |
| Elizabeth Banks | Avery Jessup | 5 | |
| Julianne Moore | Nancy Donovan | 4 | |
| Michael Sheen | Wesley | 3 | |
| 4.22 – I Do Do | Jason Sudeikis | Floyd | 12 |
| Elizabeth Banks | Avery Jessup | 6 | |
| Julianne Moore | Nancy Donovan | 5 | |
| Michael Sheen | Wesley | 4 | |
| Paula Pell | Paula | 4 | |
| Will Forte | Paul | 2 | |
| Matt Damon | Carol | 1 | |
| Season |
5 |
||
| 5.01 – The Fabian Strategy | Matt Damon | Carol | 2 |
| Paula Pell | Paula | 5 | |
| 5.02 – When it Rains, it Pours | Chris Parnell | Dr. Spaceman | 14 |
| Elizabeth Banks | Avery Jesup | 7 | |
| Sherri Shepherd | Angie Jordan | 7 | |
| Brian Williams | Himself | 4 | |
| Paul Giamatti | Ritchie | 1 | |
| Andrea Mitchell | Herself | 1 | |
| Ben Bailey | Himself | 1 | |
| 5.03 – Let’s Stay Together | Queen Latifah | Regina Bookman | 1 |
| Rob Reiner | Himself | 1 | |
| 5.04 – Live Show | Chris Parnell | Dr. Spaceman | 15 |
| Rachel Dratch | Jadwiga | 12 | |
| Chyenne Jackson | Danny | 6 | |
| Jon Hamm | Dr. Drew Baird | 6 | |
| Matt Damon | Carol | 3 | |
| Julia Louis-Dreyfus | Liz Lemon | 1 | |
| Bill Hader | Kevin | 1 | |
| 5.05 – Reaganing | Kelsey Grammer | Himself | 1 |
| 5.06 – Gentleman’s Intermission | Elizabeth Banks | Avery | 8 |
| Meredith Vieira | Herself | 5 | |
| Lester Holt | Himself | 4 | |
| Matt Lauer | Himself | 3 | |
| Buck Henry | Dick Lemon | 2 | |
| Ann Curry | Herself | 1 | |
| 5.07 – Brooklyn Without Limits | John Slattery | Steve Austin | 1 |
| 5.09 – Chain Reaction of Mental Anguish | Will Forte | Paul | 3 |
| 5.10 – Christmas Attack Zone | Elizabeth Banks | Avery Jessup | 9 |
| Elaine Stritch | Colleen Donaghy | 6 | |
| Will Forte | Paul | 4 | |
| Alan Alda | Milton Greene | 3 | |
| 5.11 – Mrs. Donaghy | Chris Parnell | Dr. Spaceman | 16 |
| Sherri Shepherd | Angie Jordan | 8 | |
| Chyenne Jackson | Danny | 7 | |
| 5.12 – Operation Righteous Cowboy Lightning | Dean Winters | Dennis Duffy | 9 |
| Sherri Shepherd | Angie Jordan | 9 | |
| Lester Holt | Himself | 5 | |
| Robert De Niro | Himself | 1 | |
| 5.13 – Que Sorpresa | Elizabeth Banks | Avery Jessup | 9 |
| Brian Williams | Himself | 5 | |
| Ken Howard | Hank Hooper | 1 | |
| Vanessa Minnillo | Carmen Chao | 1 | |
| Richard Belzer | Sgt. Munch | 1 | |
| Ice-T | Det. Fin | 1 | |
| 5.14 – Double-Edged Sword | Elizabeth Banks | Avery Jessup | 10 |
| Matt Damon | Carol Burnett | 4 | |
| John Cho | Lorne | 1 | |
| 5.15 – Its Never Too Late For Now | Eion Bailey | Anders | 1 |
| 5.16 – TGS Hates Women | Chloe Moretz | Kaylie Hooper | 1 |
| 5.17 – Queen of Jordan | Sherri Shepherd | Angie Jordan | 9 |
| Susan Sarandon | Lynn Onkman | 1 | |
| 5.18 – Plan B | Will Arnett | Devon Banks | 7 |
| Ken Howard | Hank Hooper | 2 | |
| Aaron Sorkin | Himself | 1 | |
| 5.19 – I Heart Connecticut | Rob Riggle | Rggie | 1 |
| 5.20 & 5.21 – 100 | Chris Parnell | Dr. Leo Spaceman | 17 |
| Rachel Dratch | Blue Dude & Greta | 13 | |
| Dean Winters | Dennis Duffy | 10 | |
| Brian Williams | Himself | 6 | |
| Cheyenne Jackson | Danny | 8 | |
| Will Forte | Paul | 5 | |
| Matt Lauer | Himself | 4 | |
| Ken Howard | Hank Hooper | 3 | |
| Michael Keaton | Tom | 1 | |
| Tom Hanks | Himself | 1 | |
| Regis Philbin | Himself | 1 | |
| Kelly Ripa | Herself | 1 | |
| Rachel Ray | Herself | 1 | |
| 5.22 – Everything Sunny All the Time Always | Elizabeth Banks | Avery Jessup | 11 |
| Margaret Cho | Kim Jong Il | 1 | |
| Condoleezza Rice | Herself | 1 | |
| 5.23 – Respawn | Chris Parnell | Dr. Spaceman | 19 |
| Will Forte | Paul | 6 | |
| Victor Garber | Eugene Gremby | 1 | |
| Ina Garten | Herself | 1 | |
| Season |
6 |
||
| 6.01 – Dance Like Nobody’s Watching | John McEnroe | Himself | 3 |
| 6.02 – Idiots Are People Two! | Kelsey Grammer | Himself | 2 |